Impact of cefiderocol on Klebsiella pneumoniae: A population-based longitudinal analysis of phenotypic and genotypic responses at subinhibitory and inhibitory concentrations.

Abstract excerpt

OBJECTIVE: Cefiderocol (FDC) is a siderophore cephalosporin active against carbapenem-resistant Klebsiella pneumoniae, but resistance has emerged, often involving iron-uptake pathways and β-lactamases. We investigated how an NDM-producing clinical isolate adapts to FDC under stepwise selective pressure. METHODS: A ST147 K. pneumoniae isolate (Kp-1) carrying blaNDM-5 and blaOXA-181, susceptible to FDC but...

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