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Article

Genetic basis of cefiderocol resistance in Acinetobacter baumannii: insights from functional genomics and clinical isolates.

Microbiology spectrum - 3 Mar 2026

Rome Kevin J, Mediavilla José R, Terlecky Austin J, Bucich Mia J, Shashkina Elena, Jiang Jianping, Kunkle Dillon, Rojtman Albert, Skaar Eric, Chen Liang, Kreiswith Barry N

Abstract excerpt

Cefiderocol (CFDC) is a siderophore-conjugated cephalosporin that hijacks bacterial iron uptake pathways to traverse the outer membrane, offering potent activity against carbapenem-resistant Acinetobacter baumannii (CRAB). Although mutations in pirA, a TonB-dependent siderophore receptor, have been linked to CFDC resistance, the broader genetic basis remains poorly defined. Using Himar1 transposon mutagenesis in...

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PMID: 41660850
DOI: 10.1128/spectrum.03804-25
PMCID: PMC12955420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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