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NDM-5 and siderophore receptor mutations drive high-level cefiderocol resistance in Klebsiella pneumoniae: a case series.

Infection - 1 Feb 2026

Potter Michelle H, Askar Wajih, Gomez-Abundis Gerardo F, Carpenter Kent, Kobic Emir

Abstract excerpt

BACKGROUND: Infections with Carbapenem-resistant Enterobacterales (CREs) are a serious public health threat. The emergence of distinct New Delhi metallo-beta-lactamase (NDM)-producing K. pneumoniae strains resistant to cefiderocol is a significant concern given the limited armamentarium for these carbapenemases. METHODS: A case series of 12 patients was described from a single institution that had...

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PMID: 41032192
DOI: 10.1007/s15010-025-02647-0

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