Article
Genomic and transcriptomic analyses of colistin-resistant clinical isolates of Klebsiella pneumoniae reveal multiple pathways of resistance.
Antimicrobial agents and chemotherapy - 1 Jan 2015
Wright Meredith S, Suzuki Yo, Jones Marcus B, Marshall Steven H, Rudin Susan D, van Duin David, Kaye Keith, Jacobs Michael R, Bonomo Robert A, Adams Mark D
Abstract excerpt
The emergence of multidrug-resistant (MDR) Klebsiella pneumoniae has resulted in a more frequent reliance on treatment using colistin. However, resistance to colistin (Col(r)) is increasingly reported from clinical settings. The genetic mechanisms that lead to Col(r) in K. pneumoniae are not fully characterized. Using a combination of genome sequencing and transcriptional profiling by RNA sequencing (RNA-Seq)...
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