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Article

In vitro resistance development gives insights into molecular resistance mechanisms against cefiderocol.

The Journal of antibiotics - 1 Nov 2024

Kriz Richard, Spettel Kathrin, Pichler Alina, Schefberger Katharina, Sanz-Codina Maria, Lötsch Felix, Harrison Nicole, Willinger Birgit, Zeitlinger Markus, Burgmann Heinz, Lagler Heimo

Abstract excerpt

Cefiderocol, a novel siderophore cephalosporin, demonstrates promising in vitro activity against multidrug-resistant Gram-negative bacteria, including carbapenemase-producing strains. Nonetheless, only a few reports are available regarding the acquisition of resistance in clinical settings, primarily due to its recent usage. This study aimed to investigate cefiderocol resistance using an in vitro resistance...

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Identifiers

PMID: 39080477
DOI: 10.1038/s41429-024-00762-y
PMCID: PMC11513634

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