EnvZ mutation-driven downregulation of catecholate siderophore receptors and concurrent TonB complex repression confer cefiderocol resistance in a KPC-producing ST11-KL64 hypervirulent Klebsiella pneumoniae.

Abstract excerpt

OBJECTIVES: Cefiderocol is an ultimate antibiotic option for Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP). While resistance often involves metallo-β-lactamases, mechanisms in KPC-producing strains are unclear. This study aimed to elucidate novel cefiderocol resistance mechanisms in a clinical KPC-producing ST11-KL64 CR-hvKP isolate. METHODS: Cefiderocol-resistant mutants were generated...

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