Article
[Application of polygenic risk score-based comprehensive breast cancer risk assessment in preimplantation embryo selection for a BRCA1 mutation carrier].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences - 25 May 2026
Ye Yinghui, Hu Xiaoling, Yan Kai, Yu Jialing, Chen Yulin, Zou Yangyun, Luo Qiong, Zhang Dan, Zhu Yimin, Huang Hefeng
Abstract excerpt
A patient, whose family carried a BRCA1: c.5154G>A pathogenic variant, had experienced infertility for three years and sought assisted reproductive technology. We constructed a breast cancer polygenic risk score (PRS)-313 model by integrating genetic data from breast cancer patients and controls in the UK Biobank with Asian population-specific single nucleotide polymorphism weights. Following controlled ovarian...
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