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Article

Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Nov 2020

Lakeman Inge M M, Rodríguez-Girondo Mar, Lee Andrew, Ruiter Rikje, Stricker Bruno H, Wijnant Sara R A, Kavousi Maryam, Antoniou Antonis C, Schmidt Marjanka K, Uitterlinden André G, van Rooij Jeroen, Devilee Peter

Abstract excerpt

PURPOSE: We evaluated the performance of the recently extended Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a Dutch prospective cohort, using a polygenic risk score (PRS) based on 313 breast cancer (BC)-associated variants (PRS313) and other, nongenetic risk factors. METHODS: Since 1989, 6522 women without BC aged 45 or older of European descent have...

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Identifiers

PMID: 32624571
DOI: 10.1038/s41436-020-0884-4
PMCID: PMC7605432

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