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Article

Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Breast Cancer Risk Prediction Among Asian Women.

JAMA network open - 1 Mar 2022

Yang Yaohua, Tao Ran, Shu Xiang, Cai Qiuyin, Wen Wanqing, Gu Kai, Gao Yu-Tang, Zheng Ying, Kweon Sun-Seog, Shin Min-Ho, Choi Ji-Yeob, Lee Eun-Sook, Kong Sun-Young, Park Boyoung, Park Min Ho, Jia Guochong, Li Bingshan, Kang Daehee, Shu Xiao-Ou, Long Jirong, Zheng Wei

Abstract excerpt

Importance: Polygenic risk scores (PRSs) have shown promise in breast cancer risk prediction; however, limited studies have been conducted among Asian women. Objective: To develop breast cancer risk prediction models for Asian women incorporating PRSs and nongenetic risk factors. Design, Setting, and Participants: This diagnostic study included women of Asian ancestry from the Asia Breast Cancer Consortium. PRSs...

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Asian People
Breast Neoplasms
Genetic Predisposition to Disease
Risk Factors

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PMID: 35311964
DOI: 10.1001/jamanetworkopen.2021.49030
PMCID: PMC8938714

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