Article

Technical and ethical challenges in polygenic embryo selection

2024-06-03

Abstract excerpt

Whereas best practice of clinical prediction of human phenotypes by polygenic risk score (PRS) has yet to be fully implemented, commercial industries already offer pre-implantation genetic testing for PRS (PGT-P) to select embryos with ‘desirable’ potential. However, its efficacy is questionable due to the current technical challenges, which also raise ethical concerns. Our in-silico simulations utilizing biobank...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e1f8d503-6d26-5ad2-9697-8e68fd55c920
DOI: 10.1101/2024.05.28.24308092

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Technical and ethical challenges in polygenic embryo selectionDOI 10.1101/2024.05.28.24308092Read

PREIMPLANTATION GENETIC TESTING: Preimplantation genetic testing for polygenic disease riskSemantic proximity Read

Embryo Screening for Polygenic Disease Risk: Recent Advances and Ethical Considerations.Semantic proximity Read

Utility of polygenic embryo screening for disease depends on the selection strategy.Semantic proximity Read

Utility and First Clinical Application of Screening Embryos for Polygenic Disease Risk ReductionSemantic proximity Read

Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations.Semantic proximity Read

Utility of polygenic embryo screening for disease depends on the selection strategySemantic proximity Read

Clinical utility of polygenic risk scores for embryo selection: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG)Semantic proximity Read

<i>PEStimate</i> : Predicting offspring disease risk after Polygenic Embryo ScreeningSemantic proximity Read

Polygenic risk score for embryo selection-not ready for prime time.Semantic proximity Read

Polygenic embryo screening: four clinical considerations warrant further attention.Semantic proximity Read

Prioritizing embryos with lower homozygosity is expected to reduce disease risk in children of related individuals undergoing preimplantation genetic testingSemantic proximity Read

PEStimate: predicting offspring disease risk after polygenic embryo screening.Semantic proximity Read