Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Embryo Screening for Polygenic Disease Risk: Recent Advances and Ethical Considerations.

Genes - 21 Jul 2021

Tellier Laurent C A M, Eccles Jennifer, Treff Nathan R, Lello Louis, Fishel Simon, Hsu Stephen

Abstract excerpt

Machine learning methods applied to large genomic datasets (such as those used in GWAS) have led to the creation of polygenic risk scores (PRSs) that can be used identify individuals who are at highly elevated risk for important disease conditions, such as coronary artery disease (CAD), diabetes, hypertension, breast cancer, and many more. PRSs have been validated in large population groups across multiple...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Associations and Epidemiology

Share to Genetic Predisposition to Disease

Share to Genetic Testing

Share to Multifactorial Inheritance

Share to Prenatal Screening and Diagnostics

Source

Open in PubMed Open full text

Identifiers

PMID: 34440279
DOI: 10.3390/genes12081105
PMCID: PMC8393569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Embryo Screening for Polygenic Disease Risk: Recent Advances and Ethical Considerations.PMID 34440279Read ↗

Utility and First Clinical Application of Screening Embryos for Polygenic Disease Risk ReductionSemantic proximity Read ↗

Clinical utility of polygenic risk scores for embryo selection: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG)Semantic proximity Read ↗

Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations.Semantic proximity Read ↗

PREIMPLANTATION GENETIC TESTING: Preimplantation genetic testing for polygenic disease riskSemantic proximity Read ↗

Technical and ethical challenges in polygenic embryo selectionSemantic proximity Read ↗

Polygenic risk score for embryo selection-not ready for prime time.Semantic proximity Read ↗

<i>PEStimate</i> : Predicting offspring disease risk after Polygenic Embryo ScreeningSemantic proximity Read ↗

PEStimate: predicting offspring disease risk after polygenic embryo screening.Semantic proximity Read ↗

Utility of polygenic embryo screening for disease depends on the selection strategy.Semantic proximity Read ↗

Polygenic embryo screening: four clinical considerations warrant further attention.Semantic proximity Read ↗

Development and validation of polygenic scores for within-family prediction of disease risksSemantic proximity Read ↗

Whole-genome risk prediction of common diseases in human preimplantation embryosSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.