Article
Prospective evaluation of a breast-cancer risk model integrating classical risk factors and polygenic risk in 15 cohorts from six countries.
International journal of epidemiology - 6 Jan 2022
Hurson Amber N, Pal Choudhury Parichoy, Gao Chi, Hüsing Anika, Eriksson Mikael, Shi Min, Jones Michael E, Evans D Gareth R, Milne Roger L, Gaudet Mia M, Vachon Celine M, Chasman Daniel I, Easton Douglas F, Schmidt Marjanka K, Kraft Peter, Garcia-Closas Montserrat, Chatterjee Nilanjan
Abstract excerpt
BACKGROUND: Rigorous evaluation of the calibration and discrimination of breast-cancer risk-prediction models in prospective cohorts is critical for applications under clinical guidelines. We comprehensively evaluated an integrated model incorporating classical risk factors and a 313-variant polygenic risk score (PRS) to predict breast-cancer risk. METHODS: Fifteen prospective cohorts from six countries with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.