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Article

PPARγ Variant rs10865710 and Mortality in Pediatric Septic Shock Stratified by Corticosteroid Exposure.

Critical care explorations - 1 Jun 2026

Bonnefil Valentina, Standage Stephen, Lautz Andrew J, Stanski Natalja L, Harmon Kelli, Lahni Patrick, Fitzgerald Julie C, Schwarz Adam J, Thomas Neal J, Haileselassie Bereketeab, Zingarelli Basilia, Kaplan Jennifer M, Atreya Mihir R

Abstract excerpt

OBJECTIVES: To determine whether genetic variation in peroxisome proliferator-activated receptor gamma (PPARγ) is associated with mortality across corticosteroid exposure strata in pediatric septic shock. DESIGN: Multicenter prospective observational study. SETTING: PICUs at multiple U.S. hospitals. PATIENTS: Children 1 week to 10 years old meeting consensus criteria for septic shock. INTERVENTIONS: None....

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Identifiers

PMID: 42183751
DOI: 10.1097/CCE.0000000000001410
PMCID: PMC13201038

Genes

NR3C1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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