Article
Enhancer polymorphism rs10865710 associated with traumatic sepsis is a regulator of PPARG gene expression.
Critical care (London, England) - 30 Dec 2019
Lu Hongxiang, Wen Dalin, Sun Jianhui, Zeng Ling, Du Juan, Du Dingyuan, Zhang Lianyang, Deng Jin, Jiang Jianxin, Zhang Anqiang
Abstract excerpt
BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARγ) is a major regulator in sepsis. Our previous study identified the enhancer polymorphism rs10865710C/G to be associated with susceptibility to sepsis in trauma patients. We performed two-stage cohort studies integrating biological experiments of potential functional variants that modify susceptibility to traumatic sepsis. METHODS: Improved...
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