Article
Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock.
PloS one - 1 Jan 2014
Schäfer Simon T, Gessner Sophia, Scherag André, Rump Katharina, Frey Ulrich H, Siffert Winfried, Westendorf Astrid M, Steinmann Jörg, Peters Jürgen, Adamzik Michael
Abstract excerpt
BACKGROUND: Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be evoked by genetic variations. Such candidate is a promoter polymorphism (-94ins/delATTG) of the gene encoding the ubiquitous transcription-factor nuclear-factor-κB (NF-κB) which binds to recognition elements in the promoter of several genes...
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