A single nucleotide polymorphism in the corticotropin receptor gene is associated with a blunted cortisol response during pediatric critical illness.

doi:10.1097/PCC.0000000000000193

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Article

A single nucleotide polymorphism in the corticotropin receptor gene is associated with a blunted cortisol response during pediatric critical illness.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies - 1 Oct 2014

Jardine David, Emond Mary, Meert Kathleen L, Harrison Rick, Carcillo Joseph A, Anand Kanwaljeet J S, Berger John, Newth Christopher J L, Willson Douglas F, Nicholson Carol, Dean J Michael, Zimmerman Jerry J

Abstract excerpt

OBJECTIVES: The cortisol response during critical illness varies widely among patients. Our objective was to examine single nucleotide polymorphisms in candidate genes regulating cortisol synthesis, metabolism, and activity to determine if genetic differences were associated with variability in the cortisol response among critically ill children. DESIGN: This was a prospective observational study employing tag...

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PMID: 25055195
DOI: 10.1097/PCC.0000000000000193
PMCID: PMC4712687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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