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Article

Single nucleotide polymorphisms and type of steroid impact the functional response of the human glucocorticoid receptor.

The Journal of surgical research - 1 Mar 2013

Baker Aaron C, Chew Victoria W, Green Tajia L, Tung Kelly, Lim Debora, Cho Kiho, Greenhalgh David G

Abstract excerpt

BACKGROUND: Clinical trials evaluating the use of steroids in septic shock have shown variable outcomes. Our previous studies have implicated human glucocorticoid receptor (hGR) polymorphisms as a possible cause of altered steroid response. To further evaluate this variability, we hypothesized that hGR polymorphisms along with type of steroid influence the functional response. METHODS: Total RNA was isolated from...

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Identifiers

PMID: 23333190
DOI: 10.1016/j.jss.2012.12.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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