Developing a clinically feasible personalized medicine approach to pediatric septic shock.

doi:10.1164/rccm.201410-1864OC

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Article

Developing a clinically feasible personalized medicine approach to pediatric septic shock.

American journal of respiratory and critical care medicine - 1 Feb 2015

Wong Hector R, Cvijanovich Natalie Z, Anas Nick, Allen Geoffrey L, Thomas Neal J, Bigham Michael T, Weiss Scott L, Fitzgerald Julie, Checchia Paul A, Meyer Keith, Shanley Thomas P, Quasney Michael, Hall Mark, Gedeit Rainer, Freishtat Robert J, Nowak Jeffrey, Shekhar Raj S, Gertz Shira, Dawson Emily, Howard Kelli, Harmon Kelli, Beckman Eileen, Frank Erin, Lindsell Christopher J

Abstract excerpt

RATIONALE: Using microarray data, we previously identified gene expression-based subclasses of septic shock with important phenotypic differences. The subclass-defining genes correspond to adaptive immunity and glucocorticoid receptor signaling. Identifying the subclasses in real time has theranostic implications, given the potential for immune-enhancing therapies and controversies surrounding adjunctive...

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PMID: 25489881
DOI: 10.1164/rccm.201410-1864OC
PMCID: PMC4351580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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