Article
beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock.
American journal of respiratory and critical care medicine - 15 Jan 2010
Nakada Taka-Aki, Russell James A, Boyd John H, Aguirre-Hernandez Rosalia, Thain Katherine R, Thair Simone A, Nakada Emiri, McConechy Melissa, Walley Keith R
Abstract excerpt
RATIONALE: The CysGlyGln haplotype of the beta(2)-adrenergic receptor gene (ADRB2) is functional and associated with altered responses to adrenergic agonists in patients with asthma. Whether this functional haplotype alters outcome in patients receiving adrenergic agonists in septic shock is unknown. OBJECTIVES: To determine whether genetic variation of ADRB2 influences outcome in septic shock. METHODS: Two...
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