A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock.

doi:10.4049/jimmunol.1002864

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Article

A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2011

Thair Simone A, Walley Keith R, Nakada Taka-aki, McConechy Melissa K, Boyd John H, Wellman Hugh, Russell James A

Abstract excerpt

We tested the hypothesis that single nucleotide polymorphisms (SNPs) within genes of the NF-κB pathway are associated with altered clinical outcome of septic shock patients. We genotyped 59 SNPs in the NF-κB pathway in a discovery cohort of septic shock patients (St. Paul's Hospital [SPH], N = 589), which identified the C allele of rs7222094 T/C within MAP3K14 (NF-κB inducing kinase; NIK) associated with...

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PMID: 21257964
DOI: 10.4049/jimmunol.1002864

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