A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock.

doi:10.1164/rccm.201403-0586OC

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Article

A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock.

American journal of respiratory and critical care medicine - 15 Sept 2014

Meyer Nuala J, Ferguson Jane F, Feng Rui, Wang Fan, Patel Parth N, Li Mingyao, Xue Chenyi, Qu Liming, Liu Yichuan, Boyd John H, Russell James A, Christie Jason D, Walley Keith R, Reilly Muredach P

Abstract excerpt

RATIONALE: Death from infection is a highly heritable trait, yet there are few genetic variants with known mechanism influencing survival during septic shock. OBJECTIVES: We hypothesized that a synonymous coding variant in the IL-1 receptor antagonist gene (IL1RN), rs315952, previously associated with reduced risk for acute respiratory distress syndrome, would be functional and associate with improved survival in...

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Identifiers

PMID: 25089931
DOI: 10.1164/rccm.201403-0586OC
PMCID: PMC4214110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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