Article
KDM6A mutations promote acute cytoplasmic DNA release, DNA damage response and mitosis defects.
BMC molecular and cell biology - 26 Oct 2021
Koch J, Lang A, Whongsiri P, Schulz W A, Hoffmann M J, Greife A
Abstract excerpt
BACKGROUND: KDM6A, encoding a histone demethylase, is one of the top ten mutated epigenetic cancer genes. The effect of mutations on its structure and function are however poorly characterized. METHODS: Database search identified nonsense and missense mutations in the N-terminal TPR motifs and the C-terminal, catalytic JmjC domain, but also in the intrinsically disordered region connecting both these two...
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