Article

Sensitive detection of copy number alterations in samples with low circulating tumor DNA fraction

2024-05-06

Abstract excerpt

Copy number analysis is an important aspect of cancer genomics that enables identification of activated oncogenes, inactivated tumor suppressor genes and genome-wide signatures such as homologous recombination deficiency and the tandem duplication phenotype. Despite continuous development of copy number algorithms, the current sensitivity to detect clinically relevant focal alterations is poor if the cancer DNA fr...

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Literature Corpus work: f20e47d8-6cc3-5cf4-82ee-267c2403099c
DOI: 10.1101/2024.05.04.24306860

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