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Article

Plasma ApoE proteotyping for ApoE ε4 stratification in the anti-amyloid therapies era.

Alzheimer's research & therapy - 21 May 2026

Coraglia Federico, Cecchetti Giordano, Rugarli Giulia, Spinelli Edoardo G, Ghirelli Alma, Pisano Stefano, Canu Elisa, Filippi Massimo, Agosta Federica

Abstract excerpt

BACKGROUND: Apolipoprotein E (ApoE) ε4 status informs risk stratification and safety management for anti-amyloid therapies, but genotyping typically requires dedicated procedures, longer turnaround times, and higher costs compared with automated laboratory assays. We evaluated an automated plasma approach for ε4 stratification based on proteotyping, the quantification of isoform-specific ApoE proteins to infer...

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Identifiers

PMID: 42169086
DOI: 10.1186/s13195-026-02089-2
PMCID: PMC13403392

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