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Article

Serum as an alternative to plasma for determining the ApoE4 phenotype using Pan-ApoE and ApoE4 chemiluminescent enzyme immunoassays.

Clinical chemistry and laboratory medicine - 24 Aug 2026

Kortmann Eric, Steinacker Petra, Guthknecht Arthur, Weise Christopher M, Otto Markus

Abstract excerpt

OBJECTIVES: Since apolipoprotein E4 (ApoE4) is associated with therapy-related adverse effects of anti-amyloid-β monoclonal antibodies in Alzheimer's disease, such as amyloid-related imaging abnormalities, methods for determining the ApoE4 status are needed. The Lumipulse® ApoE4 and Pan-ApoE assays provide a practical approach, but they have so far been validated only in plasma. METHODS: Plasma and serum obtained...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41842840
DOI: 10.1515/cclm-2026-0032

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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