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Article

An automated plasma-based proteotyping immunoassay for APOE ε4 zygosity classification in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2026

Levin Scott, Engel Brian, Carlson Corey, Hinson Jeremiah, Holland Mark, Figdore Dan, Lim Hyun Kook, Tiers Laurent, Bhatt Kinal, Schlichtmann Ben, Hoffmann Katie, Bae Ye Eun, Szabo Miklos, Lehmann Sylvain, Um Yoo Hyun, Algeciras-Schimnich Alicia

Abstract excerpt

INTRODUCTION: Determining apolipoprotein E (APOE) ε4 allele status, a key genetic risk factor for Alzheimer's disease (AD), requires molecular genotyping infrastructure not widely accessible beyond specialized centers. METHODS: A fully automated high-throughput apoE E4 proteotyping immunoassay was evaluated for clinical performance (460 participants across three cohorts) and analytical validity. Concordance with...

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Aged, 80 and over
Alzheimer Disease
Apolipoprotein E4
Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotyping Techniques

Polymerase Chain Reaction

Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 41789706
DOI: 10.1002/alz.71143
PMCID: PMC12964312

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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