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Article

Evaluation of two plasma-based proteotyping assays against APOE ε4 genotyping in a memory clinic setting: The Gothenburg H70 Clinical Studies.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2025

Dittrich Anna, Blennow Kaj, Tan Kübra, Benedet Andrea L, Skoog Ingmar, Höglund Kina, Ashton Nicholas J, Zetterberg Henrik, Kern Silke

Abstract excerpt

INTRODUCTION: Apolipoprotein E (APOE) ε4 allele status is associated with an increased risk of Alzheimer's disease and should be determined prior to initiation of anti-amyloid beta antibody treatment, because of increased risk of treatment-related side effects. Plasma-based apoE4 proteotyping may be an alternative to genotyping, with limited clinical evidence. METHODS: apoE4 proteotyping was performed on 164...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39988952
DOI: 10.1002/alz.14610
PMCID: PMC11847986

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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