Article
Ppm1d Clonal Hematopoiesis Does Not Promote Atherosclerosis in Murine Models.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2026
De Jeronimo Diaz Cesar, Liao Huajun, Hardaway Brian, Li Linke, Gan Anna Lu, Liu Mandy, Kim Alice, Qian Grace, Abramowicz Sandra, Lam Edithe, Tseng Zian H, Devine W Patrick, Tall Alan R, Yu Zhi, Miller Peter G, Ebert Benjamin L, Fidler Trevor P
Abstract excerpt
BACKGROUND: Clonal hematopoiesis (CH) is an age-associated condition common in the elderly that arises when hematopoietic stem cells acquire somatic mutations in an assortment of genes, most commonly DNMT3A, TET2, ASXL1, PPM1D, and JAK2. CH is associated with increased coronary artery disease and all-cause mortality. Epidemiological studies have revealed that different CH driver mutations are associated with...
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