Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes.

doi:10.1038/s44161-023-00326-7

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Article

Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes.

Nature cardiovascular research - 1 Sept 2023

Rauch Philipp J, Gopakumar Jayakrishnan, Silver Alexander J, Nachun Daniel, Ahmad Herra, McConkey Marie, Nakao Tetsushi, Bosse Marc, Rentz Thiago, Vivanco Gonzalez Nora, Greenwald Noah F, McCaffrey Erin F, Khair Zumana, Gopakumar Manu, Rodrigues Kameron B, Lin Amy E, Sinha Eti, Fefer Maia, Cohen Drew N, Vromman Amélie, Shvartz Eugenia, Sukhova Galina, Bendall Sean, Angelo Michael, Libby Peter, Ebert Benjamin L, Jaiswal Siddhartha

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the presence of a cancer-associated somatic mutation in white blood cells in the absence of overt hematological malignancy. It arises most commonly from loss-of-function mutations in the epigenetic regulators DNMT3A and TET2. CHIP predisposes to both hematological malignancies and atherosclerotic cardiovascular disease in humans. Here we...

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PMID: 39196062
DOI: 10.1038/s44161-023-00326-7

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