CH-related Mutant ASXL1 Promotes Atherosclerosis in Mice via Dysregulated Innate Immunity

Abstract excerpt

<h4>Summary</h4> Certain somatic mutations confer a fitness advantage in hematopoietic stem and progenitor cells (HSPCs) over normal HSPCs, resulting in the clonal expansion of mutant blood cells 1 , otherwise known as clonal haematopoiesis (CH). CH is frequently observed among healthy elderly people and is closely associated with the risk of cardiovascular diseases (CVDs). The most frequently mutated genes of C...

Topics

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• Aortic Diseases
• Atherosclerosis
• Clonal Hematopoiesis
• Interleukin-1 Receptor-Associated Kinases
• MAP Kinase Kinase Kinases
• Monocytes
• NF-kappa B
• Plaque, Atherosclerotic

Identifiers and source

Literature Corpus work

e68de1ea-61df-5a1a-a762-45805f46b768

DOI

10.1101/2024.08.18.608516