Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity.

doi:10.1038/s44161-024-00579-w

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Article

Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity.

Nature cardiovascular research - 1 Dec 2024

Sato Naru, Goyama Susumu, Chang Yu-Hsuan, Miyawaki Masashi, Fujino Takeshi, Koide Shuhei, Denda Tamami, Liu Xiaoxiao, Ueda Koji, Yamamoto Keita, Asada Shuhei, Takeda Reina, Yonezawa Taishi, Tanaka Yosuke, Honda Hiroaki, Ota Yasunori, Shibata Takuma, Sekiya Motohiro, Isobe Tomoya, Lamagna Chrystelle, Masuda Esteban, Iwama Atsushi, Shimano Hitoshi, Inoue Jun-Ichiro, Miyake Kensuke, Kitamura Toshio

Abstract excerpt

Certain somatic mutations provide a fitness advantage to hematopoietic stem cells and lead to clonal expansion of mutant blood cells, known as clonal hematopoiesis (CH). Among the most common CH mutations, ASXL1 mutations pose the highest risk for cardiovascular diseases (CVDs), yet the mechanisms by which they contribute to CVDs are unclear. Here we show that hematopoietic cells harboring C-terminally truncated...

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PMID: 39653824
DOI: 10.1038/s44161-024-00579-w

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