Article
No Effect of Ppm1d-Mutant Clonal Hematopoiesis on Atherosclerosis Development in Mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2026
Amorós-Pérez Marta, Zuriaga María A, Zorita Virginia, Ramos-Neble Beatriz L, Matesanz Nuria, Plötner Clara, Di Carli Milena, Mol Eline L C, Moro Rosa, Cuevas Diego, Andrés Vicente, Fuster José J
Abstract excerpt
BACKGROUND: Clonal hematopoiesis driven by somatic mutations is an emerging cardiovascular risk factor, and the DNA damage response gene PPM1D is among the most frequently mutated genes. Mutations in PPM1D are enriched in cancer patients and survivors, where cytotoxic therapies promote the expansion of mutant clones, a condition termed therapy-related clonal hematopoiesis. Although PPM1D-mutant clonal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.