Hematopoietic somatic mutations in atherosclerotic cardiovascular disease.

Abstract excerpt

Age-related somatic mosaicism in the hematopoietic system is increasingly recognized as a risk factor for atherosclerotic cardiovascular disease. The most prominent example is clonal hematopoiesis of indeterminate potential (CHIP), defined as the expansion of hematopoietic clones carrying acquired mutations in genes recurrently mutated in myeloid hematological malignancies, typically at a variant allele fraction...

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