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Article

Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis.

JCI insight - 9 Feb 2026

Carter Paul R, Kitt Lauren, Rodgers Amanda C, Figg Nichola, Zhou Ang, Zhu Chengrui, Wang Ziyang, Libby Peter, Burgess Stephen, Vassiliou George S, Clarke Murray Ch

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is the expansion of blood stem cells and progeny after somatic mutation. CHIP associates with increased cardiovascular disease (CVD), with inflammation from macrophages a proposed common effector. However, mouse CHIP studies are discordant for clonal expansion and inflammation. Similarly, directionality of association between CHIP and CVD remains debated. We...

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Identifiers

PMID: 41433101
DOI: 10.1172/jci.insight.200334
PMCID: PMC12892922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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