Article

Serial amplification of tau filaments using Alzheimer’s brain homogenates and C322A or C322S recombinant tau

2025-04-03

Abstract excerpt

The assembly of tau into amyloid filaments is a defining characteristic of Alzheimer’s disease (AD) and other tauopathies. Cryo-electron microscopy (cryo-EM) showed that specific tau folds characterise different diseases, and that in vitro models often yield filaments with folds that do not replicate those that form in disease. Here, we investigated the aggregation of full-length recombinant 0N3R tau, using wild-...

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Literature Corpus work: 05e00df1-1d54-570a-ada7-9f497382a4af
DOI: 10.1101/2025.03.29.646137

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