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The identification Mycobacterium tuberculosis genes that modulate long term survival in the presence of rifampicin and streptomycin

1 Jul 2025

Abstract excerpt

Abstract In 2023, Mycobacterium tuberculosis (Mtb) caused 10.6 million new tuberculosis cases and 1.3 million deaths. The WHO proscribed treatment is not always successful, even when strains were sensitive to the antibiotics.as clinical Mtb populations contain phenotypically tolerant subpopulations, termed persisters. Here a Mtb transposon library was challenged with rifampicin (RIF) and streptomycin (STM) under...

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PMID: 40595703
DOI: 10.1038/s41598-025-04038-9

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