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Article

MRC2-mediated collagen internalization is reduced in fibrotic lung fibroblasts and increased upon phenotypic dedifferentiation.

JCI insight - 8 Jul 2026

Walker Natalie M, Fortier Sean M, Speth Jennifer, Huang Steven K, Gutor Sergey, Blackwell Timothy S, Peters-Golden Marc

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is characterized by parenchymal scarring reflecting an imbalance between collagen deposition by myofibroblasts (MFs) and its turnover. Although collagen clearance is essential for fibrosis resolution, this process and its potential for therapeutic modulation in IPF are poorly understood. Here we evaluated internalization of degraded collagen and the role of its requisite...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42154525
DOI: 10.1172/jci.insight.201712
PMCID: PMC13460822

Genes

MRC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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