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Article

Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype.

PloS one - 1 Jan 2017

Joshi Shweta, Singh Alok R, Wong Simon S, Zulcic Muamera, Jiang Min, Pardo Annie, Selman Moises, Hagood James S, Durden Donald L

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by cellular phenotype alterations and deposition of extracellular matrix proteins. The alternative activation of macrophages in the lungs has been associated as a major factor promoting pulmonary fibrosis, however the mechanisms underlying this phenomenon are poorly understood. In the present study, we have defined a molecular mechanism...

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Identifiers

PMID: 28817691
DOI: 10.1371/journal.pone.0182851
PMCID: PMC5560537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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