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Extracellular matrix endocytosis in controlling matrix turnover and beyond: emerging roles in cancer

15 Oct 2016

Abstract excerpt

The extracellular matrix (ECM) is a network of secreted proteins that, beyond providing support for tissues and organs, is involved in the regulation of a variety of cell functions, including cell proliferation, polarity, migration and oncogenic transformation. ECM homeostasis is maintained through a tightly controlled balance between synthesis, deposition and degradation. While the role of metalloproteases in...

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PMID: 27911717
DOI: 10.1042/bst20160159

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