Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180.

Abstract excerpt

The molecular interactions leading to organised, controlled extracellular matrix degradation are of central importance during growth, development and tissue repair, and when deregulated contribute to disease processes including cancer cell invasion. There are two major pathways for collagen degradation: one dependent on secreted and membrane-bound collagenases, the other on receptor-mediated collagen...

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