Article
Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis.
Nature communications - 18 Aug 2016
Chen Huaping, Qu Jing, Huang Xiangwei, Kurundkar Ashish, Zhu Lanyan, Yang Naiheng, Venado Aida, Ding Qiang, Liu Gang, Antony Veena B, Thannickal Victor J, Zhou Yong
Abstract excerpt
Matrix stiffening is a prominent feature of pulmonary fibrosis. In this study, we demonstrate that matrix stiffness regulates the ability of fibrotic lung myofibroblasts to invade the basement membrane (BM). We identify α6-integrin as a mechanosensing integrin subunit that mediates matrix stiffness-regulated myofibroblast invasion. Increasing α6-expression, specifically the B isoform (α6B), couples β1-integrin to...
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