Article

Lung extracellular matrix modulates KRT5 <sup>+</sup> basal cell activity in pulmonary fibrosis

2022-12-18

Abstract excerpt

Aberrant expansion of KRT5 + basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). The mechanisms determining activity of KRT5 + cells in IPF have not been delineated. Here, we reveal a potential mechanism by which KRT5 + cells migrate within the fibrotic lung, navigating regional differences in col...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b8a2533e-df48-5cd7-a710-0ad9e0a0e545
DOI: 10.1101/2022.12.16.520808

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lung extracellular matrix modulates KRT5 <sup>+</sup> basal cell activity in pulmonary fibrosisDOI 10.1101/2022.12.16.520808Read

Spatial multiomic profiling reveals distinct fibrotic epithelial niches in idiopathic pulmonary fibrosisSemantic proximity Read

Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosisSemantic proximity Read

Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1+ cells as fibrogenic signaling hubs in fibrosisSemantic proximity Read

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosisSemantic proximity Read

Trajectory inference of epithelial-centered neighborhood profiles reconstructs a pseudo-temporal continuum in idiopathic pulmonary fibrosisSemantic proximity Read

Spatial transcriptomic characterization of pathologic niches in IPFSemantic proximity Read

Single-cell RNA sequencing reveals special basal cells and fibroblasts in idiopathic pulmonary fibrosisSemantic proximity Read

Spatial Transcriptomic Characterization of Novel Pathologic Niches in IPFSemantic proximity Read

Extracellular matrix as a driver of progressive fibrosisSemantic proximity Read

Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosisSemantic proximity Read

Dysregulated Cell–Cell Communication Characterizes Pulmonary FibrosisSemantic proximity Read

Early Pulmonary Fibrosis is Defined by Niche- and Cell-Specific Molecular ProgramsSemantic proximity Read