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Article

The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)

12 Aug 2015

Abstract excerpt

The collagen receptor uPARAP/Endo180, the product of the MRC2 gene, is a central component in the collagen turnover process governed by various mesenchymal cells. Through the endocytosis of collagen or large collagen fragments, this recycling receptor serves to direct basement membrane collagen as well as interstitial collagen to lysosomal degradation. This capacity, shared only with the mannose receptor from the...

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PMID: 26316068
DOI: 10.3892/ijo.2015.3120

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