Article

Matricytosis is a phenotype-specific ECM internalization program dysregulated across macrophages and fibroblasts in pulmonary fibrosis

2026-09-01

Abstract excerpt

<title>Abstract</title> <p>Idiopathic pulmonary fibrosis (IPF) is characterized by persistent extracellular matrix (ECM) accumulation, yet the mechanisms governing ECM clearance remain poorly understood. In this study we investigate matricytosis, a program of ECM uptake and lysosomal degradation, and its status in disease. We show that matricytosis is highly phenotype-dependent in human macrophages and fibroblast...

Identifiers and source

Literature Corpus work: 0cc1b40f-9aca-590d-b165-1d953786ad2a
DOI: 10.21203/rs.3.rs-10626944/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Matricytosis is a phenotype-specific ECM internalization program dysregulated across macrophages and fibroblasts in pulmonary fibrosisDOI 10.21203/rs.3.rs-10626944/v1Read

Extracellular matrix as a driver of progressive fibrosisSemantic proximity Read

Profiling Fibrosis through Single-Cell and Spatial Transcriptomics Analysis: cell identity and tissue architectureSemantic proximity Read

Resolving the molecular niche of pulmonary fibrosis using cryopreserved human precision cut lung slicesSemantic proximity Read

Image-based spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosisSemantic proximity Read

Spatial multiomic profiling reveals distinct fibrotic epithelial niches in idiopathic pulmonary fibrosisSemantic proximity Read

Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosisSemantic proximity Read

Early Pulmonary Fibrosis is Defined by Niche- and Cell-Specific Molecular ProgramsSemantic proximity Read

Spatial transcriptomic characterization of pathologic niches in IPFSemantic proximity Read

Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary FibrosisSemantic proximity Read

<i>Ex vivo</i> tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesisSemantic proximity Read

Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosisSemantic proximity Read

Mechanisms and Therapeutic Potential of Myofibroblast Transformation in Pulmonary FibrosisSemantic proximity Read