Article
Limited redundancy of the proprotein convertase furin in mouse liver.
The Journal of biological chemistry - 17 Dec 2004
Roebroek Anton J M, Taylor Neil A, Louagie Els, Pauli Ilse, Smeijers Liesbeth, Snellinx An, Lauwers Annick, Van de Ven Wim J M, Hartmann Dieter, Creemers John W M
Abstract excerpt
Furin is an endoprotease of the family of mammalian proprotein convertases and is involved in the activation of a large variety of regulatory proteins by cleavage at basic motifs. A large number of substrates have been attributed to furin on the basis of in vitro and ex vivo data. However, no physiological substrates have been confirmed directly in a mammalian model system, and early embryonic lethality of a...
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