Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hip Bone Marrow Adiposity as a Risk Factor for Alzheimer's Disease: Insights From Mendelian Randomization Analysis.

Annals of human genetics - 1 Jul 2026

Shi Wei, Zhu Zhenhua, Wu Minghui, Cheng Wenjun, Xu Haijun

Abstract excerpt

BACKGROUND: The bone-brain axis has emerged as a critical framework linking skeletal metabolism to neurodegeneration. Within this axis, bone marrow adipose tissue (BMAT) represents a unique fat depot with distinct endocrine and hematopoietic functions, yet its contribution to Alzheimer's disease (AD) remains unclear. METHODS: We conducted a two-sample Mendelian randomization (MR) analysis using genome-wide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Adiposity
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Density

Share to Bone Marrow

Share to Femur Neck

Share to Mendelian Randomization Analysis

Source

Identifiers

PMID: 42152579
DOI: 10.1111/ahg.70041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hip Bone Marrow Adiposity as a Risk Factor for Alzheimer's Disease: Insights From Mendelian Randomization Analysis.PMID 42152579Read ↗

Unravelling the Relationship Between Height, Lean Mass, Alzheimer’s Disease and Cognition Through Mendelian RandomizationSemantic proximity Read ↗

Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank.Semantic proximity Read ↗

A Phenome-wide Association and Mendelian Randomization Study for Alzheimer's Disease: A Prospective Cohort Study of 502,493 Participants From the UK Biobank.Semantic proximity Read ↗

Fat-brain axis indicated by mutual impacts between body fat and brain phenotypes.Semantic proximity Read ↗

Causal Relationship Between Basal Metabolic Rate and Alzheimer’s Disease: A Bidirectional Two-sample Mendelian Randomization StudySemantic proximity Read ↗

Life Course Adiposity and Alzheimer's Disease: A Mendelian Randomization Study.Semantic proximity Read ↗

Genetic Insights into Obesity and Brain: Combine Mendelian Randomization Study and Gene Expression AnalysisSemantic proximity Read ↗

Causal effect of blood osteocalcin on the risk of Alzheimer's disease and the mediating role of energy metabolism.Semantic proximity Read ↗

Alzheimer’s Disease: Causal Effect between Obesity and APOE Gene PolymorphismsSemantic proximity Read ↗

Investigation of the causal relationship between osteocalcin and dementia: A Mendelian randomization studySemantic proximity Read ↗

Extension of Mendelian Randomization to Identify Earliest Manifestations of Alzheimer Disease: Association of Genetic Risk Score for Alzheimer Disease With Lower Body Mass Index by Age 50 Years.Semantic proximity Read ↗

Obesity-related brain atrophy is independent of Alzheimer’s disease protein pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.