Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fat-brain axis indicated by mutual impacts between body fat and brain phenotypes.

Journal of translational medicine - 21 Nov 2025

Baranova Ancha, Fu Li, Zhao Qian, Liu Dongming, Cao Hongbao, Chandhoke Vikas, Zhang Fuquan

Abstract excerpt

BACKGROUND: Adipose tissue and the central nervous system regulate each other, but the interactions between body fat composition and brain health remain unclear. METHODS: To investigate this, we conducted Mendelian randomization (MR) analyses to explore the causality between body fat composition, brain volume, intelligence, cognitive performance (CP), and 19 neuropsychiatric diseases using six body fat measures....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Body Mass Index
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition

Share to CP gene

Share to Mendelian Randomization Analysis

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 41272839
DOI: 10.1186/s12967-025-07453-8
PMCID: PMC12754958

Genes

CP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fat-brain axis indicated by mutual impacts between body fat and brain phenotypes.PMID 41272839Read ↗

Novel Insights Into the Causal Effects and Shared Genetics Between Body Fat and Parkinson Disease.Semantic proximity Read ↗

Adipose tissue coregulates cognitive functionSemantic proximity Read ↗

Genetic Insights into Obesity and Brain: Combine Mendelian Randomization Study and Gene Expression AnalysisSemantic proximity Read ↗

Investigating multidimensional associations between obesity-related traits and brain health, and identifying potential mechanisms.Semantic proximity Read ↗

Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellnessSemantic proximity Read ↗

Population-based body-brain mapping links brain morphology and body compositionSemantic proximity Read ↗

Distinct metabolic signatures of Alzheimer’s and Parkinson’s disease revealed through genetic overlap with metabolic markersSemantic proximity Read ↗

Hip Bone Marrow Adiposity as a Risk Factor for Alzheimer's Disease: Insights From Mendelian Randomization Analysis.Semantic proximity Read ↗

Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: A Mendelian randomization studySemantic proximity Read ↗

Atlas of the Human Brain Imaging-derived Phenotypes and Disease RiskSemantic proximity Read ↗

Molecular landscape of the overlap between Alzheimer’s disease and somatic insulin-related diseasesSemantic proximity Read ↗

Obesity-related brain atrophy is independent of Alzheimer’s disease protein pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.