Genetic Insights into Obesity and Brain: Combine Mendelian Randomization Study and Gene Expression Analysis

Abstract excerpt

As a major public-health concern, obesity is imposing an increasing social burden around the world. The link between obesity and brain-health problems has been reported, but controversy remains. To investigate the relationship among obesity, brain-structure changes and diseases, a two-stage analysis was performed. At first, we used the Mendelian-randomization (MR) approach to identify the causal relationship...

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