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Unravelling the Relationship Between Height, Lean Mass, Alzheimer’s Disease and Cognition Through Mendelian Randomization

21 Jan 2025

Abstract excerpt

Background: Genetic evidence from Mendelian randomization (MR) analyses suggests that higher lean mass causally protects against Alzheimer’s disease (AD) and enhances cognitive function. However, the potential confounding role of height, which shares genetic etiology with lean mass, has not been fully examined. Methods: Genetic predictors of whole-body lean mass were obtained from a genome-wide association study...

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PMID: 40004442
DOI: 10.3390/genes16020113

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