Article
Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank.
Nature communications - 23 Sept 2025
Xu Wei, Mesa-Eguiagaray Ines, Morris David M, Wang Chengjia, Gray Calum D, Sjöström Samuel, Papanastasiou Giorgos, Badr Sammy, Paccou Julien, Wang Lijuan, Li Xue, Timmers Paul R H J, Timofeeva Maria, Semple Scott Ik, MacGillivray Tom, Theodoratou Evropi, Cawthorn William P
Abstract excerpt
Bone marrow adiposity changes in diverse diseases, but the full scope of these, and whether they are directly influenced by marrow adiposity, remains unknown. To address this, we previously measured the bone marrow fat fraction of the femoral head, total hip, femoral diaphysis, and spine of over 48,000 UK Biobank participants. Here, we first use these data for PheWAS to identify diseases associated with marrow...
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